The metabolism of racemic ibuprofen is quite complex (Rudy et al
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Simulation of Separation of a Racemic Mixture of Ibuprofen by Supercritical Fluid Chromatography in Simulated Moving Bed
Separation of a racemic mixture of ibuprofen at a low concentration level by supercritical fluid chromatography in a simulated moving bed (SFC-SMB) is investigated by simulation. The feasibility of ibuprofen enantiomers separation has been experimentally examined in the literature. Our simulation results show that separation of ibuprofen enantiomers is feasible by this method, and R-ibuprofen a...
متن کاملCan the use of specific isomers improve the safety and efficacy of nonsteroidal antiinflammatory drugs?
The NSAIDs have become increasingly popular for the perioperative period because of their opioid-sparing effects and potential for reducing opioid-related side effects and improving the recovery process (4). Unfortunately, nonselective NSAIDs such as ketorolac and ibuprofen also have the ability to interfere with platelet function, as well as the potential for producing adverse effects on gastr...
متن کاملتاثیر 12 هفته تمرینات مقاومتی بر سطوح آپلین، امنتین-1 و مقاومت به انسولین در زنان مسن دارای اضافه وزن مبتلا به دیابت نوع 2
Background and Objective: Nowadays, it has been recognized that Apelin and Omentin as the hormones secreted by adipose tissue, can be effective in regulating metabolism. The purpose of the present study was to determine the impact of 12 weeks of resistance training exercises on the Apelin, Omentin-1 levels and insulin resistance in overweight elderly women suffering from type 2 diabetes. Materi...
متن کاملOral versus rectal ibuprofen in healthy volunteers.
OBJECTIVE Ibuprofen is a safe and effective non steroidal anti-inflammatory drug (NSAID). Ibuprofen suppositories are marketed in Europe; but data regarding pharmacokinetics of rectal vs. oral ibuprofen in humans is scarce. The objective of this study is to compare the pharmacokinetics of single-dose rectal vs. oral ibuprofen in healthy adult volunteers. METHODS Ten healthy adult male volunte...
متن کاملEnzymatic Hydrolytic Resolution of Racemic Ibuprofen Ethyl Ester Using an Ionic Liquid as Cosolvent.
The aim of this study was to develop an ionic liquid (IL) system for the enzymatic resolution of racemic ibuprofen ethyl ester to produce (S)-ibuprofen. Nineteen ILs were selected for use in buffer systems to investigate the effects of ILs as cosolvents for the production of (S)-ibuprofen using thermostable esterase (EST10) from Thermotoga maritima. Analysis of the catalytic efficiency and conf...
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